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GRK4
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 5 B2|5 17.91 cM |
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Cellular Component:
cytoplasm; cytosol; dendrite; neuronal cell body; plasma membrane
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Molecular Function:
ATP binding; G protein-coupled receptor kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; rhodopsin kinase activity; transferase activity
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Biological Process:
desensitization of G protein-coupled receptor signaling pathway; G protein-coupled receptor internalization; phosphorylation; protein phosphorylation; receptor internalization; regulation of signal transduction; signal transduction
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Reference #:
O70291
(UniProtKB)
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Alt. Names/Synonyms: A830025H08Rik; G protein-coupled receptor kinase 2, groucho gene related; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; Gpr; Gprk2l; Gprk4; GRK; Grk4; OTTMUSP00000026886; OTTMUSP00000026887
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Gene Symbols: Grk4
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Molecular weight:
66,928 Da
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Basal Isoelectric point:
7.4
Predict pI for various phosphorylation states
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