CYP4F3 Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 16p14
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  heme binding; iron ion binding; leukotriene-B4 20-monooxygenase activity; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Biological Process:  leukotriene B4 catabolic process; oxidation-reduction process
Reference #:  Q3MID2 (UniProtKB)
Alt. Names/Synonyms: CP4F3; Cyp4f18; Cyp4f3; CYPIVF3; Cytochrome P450 4F3; cytochrome P450, family 4, subfamily f, polypeptide 18; Cytochrome P450-LTB-omega; Leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-hydroxylase 2; MGC124833
Gene Symbols: Cyp4f3
Molecular weight: 59,906 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene