CYP2D9 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.14.1; Oxidoreductase
Chromosomal Location of Human Ortholog: 15 E1|15 38.6 cM
Cellular Component:  endoplasmic reticulum; intracellular membrane-bound organelle; membrane
Molecular Function:  heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity
Biological Process:  arachidonic acid metabolic process
Reference #:  P11714 (UniProtKB)
Alt. Names/Synonyms: Cyp2d; Cyp2d9; CYPIID9; Cytochrome P450 2D9; cytochrome P450, 2d9; Cytochrome P450, family 2, subfamily d, polypeptide 9; cytochrome P450-16-alpha; cytochrome P450CA; MCG8136, isoform CRA_b; P450-2D; testosterone 16-alpha hydroxylase; testosterone 16alpha-hydroxylase
Gene Symbols: Cyp2d9
Molecular weight: 56,950 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
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CYP2D9

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein