GRK1 Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Retinal-specific. Expressed in rods and cones cells. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16q12.5
Cellular Component:  membrane; photoreceptor outer segment
Molecular Function:  ATP binding; G protein-coupled receptor kinase activity; rhodopsin kinase activity
Biological Process:  negative regulation of apoptotic process; photoreceptor cell morphogenesis; positive regulation of phosphorylation; post-embryonic retina morphogenesis in camera-type eye; protein autophosphorylation; regulation of rhodopsin mediated signaling pathway; response to drug; response to light stimulus; rhodopsin mediated signaling pathway; signal transduction; visual perception
Reference #:  Q63651 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; Grk1; Rhodopsin kinase; Rhok; RK
Gene Symbols: Grk1
Molecular weight: 63,769 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene