GRK1 a Ser/Thr of the GRK family. Phosphorylates and inactivates photon-activated rhodopsin. LOF mutations lead to type 2 Oguchi disease, a form of night blindness. A link between RHOK and retinitis pigmentosa is now thought to be unlikely Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16q12.5
Cellular Component:  membrane; photoreceptor outer segment
Molecular Function:  ATP binding; G-protein coupled receptor kinase activity; rhodopsin kinase activity
Biological Process:  negative regulation of apoptosis; photoreceptor cell morphogenesis; positive regulation of phosphorylation; post-embryonic retina morphogenesis in camera-type eye; protein autophosphorylation; regulation of rhodopsin mediated signaling; response to drug; response to light stimulus; rhodopsin mediated signaling pathway; signal transduction; visual perception
Reference #:  Q63651 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; Grk1; Rhodopsin kinase; Rhok; RK
Gene Symbols: Grk1
Molecular weight: 63,769 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene