GRK1 Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Retinal-specific. Expressed in rods and cones cells. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.14; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8|8 A1.1
Cellular Component:  membrane; photoreceptor outer segment
Molecular Function:  ATP binding; G protein-coupled receptor kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; rhodopsin kinase activity; transferase activity
Biological Process:  negative regulation of apoptotic process; phosphorylation; photoreceptor cell morphogenesis; positive regulation of phosphorylation; post-embryonic retina morphogenesis in camera-type eye; protein autophosphorylation; protein phosphorylation; regulation of rhodopsin mediated signaling pathway; response to light stimulus; response to stimulus; signal transduction; visual perception
Reference #:  Q9WVL4 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor kinase 1; G-protein receptor kinase 1; Gprk1; Grk1; Rhodopsin kinase; Rhok; RK
Gene Symbols: Grk1
Molecular weight: 63,837 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
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GRK1

Protein Structure Not Found.


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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene