CRIK Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; CRIK subfamily; DMPK family; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 12q16
Cellular Component:  actin cytoskeleton; cleavage furrow; cytoplasm; cytosol; Golgi cisterna; midbody; neuronal cell body; ruffle; vacuole
Molecular Function:  ATP binding; metal ion binding; PDZ domain binding; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; scaffold protein binding; transcription coactivator binding
Biological Process:  dendrite development; G2/M transition of mitotic cell cycle; generation of neurons; Golgi organization; liver development; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle; mitotic cytokinesis; mitotic sister chromatid segregation; negative regulation of dendrite morphogenesis; negative regulation of hippo signaling; neuron apoptotic process; organelle organization; positive regulation of cytokinesis; protein phosphorylation; regulation of actin polymerization or depolymerization; spermatogenesis
Reference #:  E9PSL7 (UniProtKB)
Alt. Names/Synonyms: Cit; citron; citron (rho-interacting, serine/threonine kinase 21); citron kinase; Citron rho-interacting kinase; Citron rho-interacting serine/threonine kinase; citron-K kinase; CRIK; CTRO; Postsynaptic density protein; postsynaptic density protein (citron); Rho-interacting, serine/threonine-protein kinase 21
Gene Symbols: Cit
Molecular weight: 235,310 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein