CRIK an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q16
Cellular Component:  actin cytoskeleton; cleavage furrow; cytoplasm; cytoskeleton; cytosol; Golgi cisterna; midbody; neuronal cell body; nucleus; plasma membrane; ruffle; vacuole
Molecular Function:  ATP binding; metal ion binding; PDZ domain binding; protein serine/threonine kinase activity; scaffold protein binding
Biological Process:  actomyosin structure organization; cortical actin cytoskeleton organization; dendrite development; G2/M transition of mitotic cell cycle; generation of neurons; Golgi organization; intracellular signal transduction; liver development; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle; mitotic cytokinesis; mitotic sister chromatid segregation; negative regulation of dendrite morphogenesis; neuron apoptotic process; peptidyl-threonine phosphorylation; positive regulation of cytokinesis; protein phosphorylation; regulation of actin polymerization or depolymerization; spermatogenesis
Reference #:  Q9QX19 (UniProtKB)
Alt. Names/Synonyms: Cit; citron; citron (rho-interacting, serine/threonine kinase 21); citron kinase; citron Rho-interacting kinase; Citron rho-interacting serine/threonine kinase; citron-K kinase; Postsynaptic density protein; postsynaptic density protein (citron)
Gene Symbols: Cit
Molecular weight: 185,926 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene