ABCC6 Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Expressed in kidney and liver. Very low expression in other tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  apical plasma membrane; basolateral plasma membrane; integral component of membrane; lateral plasma membrane; membrane; nucleus; plasma membrane; vacuolar membrane
Molecular Function:  ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances
Biological Process:  transmembrane transport
Reference #:  O88269 (UniProtKB)
Alt. Names/Synonyms: Abcc6; ATP-binding cassette sub-family C member 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6; liver multidrug resistance-associated protein 6; MLP-1; Mlp1; MRP-like protein 1; Mrp6; Multidrug resistance-associated protein 6
Gene Symbols: Abcc6
Molecular weight: 164,995 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ABCC6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene