|
TBC1D17
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: GAP; GAP, Rab |
| Chromosomal Location of human Ortholog: 19q13.33 |
|
Cellular Component:
autophagosome; cytosol; recycling endosome
|
|
Molecular Function:
GTPase activator activity; protein binding
|
|
Biological Process:
activation of GTPase activity; autophagy; protein transport; regulation of cilium assembly; retrograde transport, endosome to Golgi
|
|
Reference #:
Q9HA65
(UniProtKB)
|
|
Alt. Names/Synonyms: FLJ12168; TBC1 domain family member 17; TBC1 domain family, member 17; TBC17; TBC1D17
|
|
Gene Symbols: TBC1D17
|
|
Molecular weight:
72,670 Da
|
|
Basal Isoelectric point:
5.08
Predict pI for various phosphorylation states
|
