ROCK2 Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); ROCK subfamily
Chromosomal Location of mouse Ortholog: 12|12 A1.1
Cellular Component:  centrosome; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoskeleton; cytosol; glutamatergic synapse; membrane; nucleus; plasma membrane; Schaffer collateral - CA1 synapse; spindle pole centrosome
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rho-dependent protein serine/threonine kinase activity; small GTPase binding; transferase activity
Biological Process:  actin cytoskeleton organization; actomyosin structure organization; blood vessel diameter maintenance; cellular response to acetylcholine; cellular response to testosterone stimulus; centrosome duplication; cortical actin cytoskeleton organization; dendrite morphogenesis; embryonic morphogenesis; epithelial to mesenchymal transition; extrinsic apoptotic signaling pathway via death domain receptors; I-kappaB kinase/NF-kappaB signaling; mitotic cytokinesis; modulation by host of viral process; mRNA destabilization; negative regulation of angiogenesis; negative regulation of bicellular tight junction assembly; negative regulation of gene expression; negative regulation of myosin-light-chain-phosphatase activity; negative regulation of nitric oxide biosynthetic process; negative regulation of protein localization to lysosome; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of amyloid precursor protein catabolic process; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cardiac muscle hypertrophy; positive regulation of cell migration; positive regulation of centrosome duplication; positive regulation of connective tissue growth factor production; positive regulation of connective tissue replacement; positive regulation of endothelial cell migration; positive regulation of fibroblast growth factor production; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein localization to early endosome; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; postsynaptic actin cytoskeleton organization; protein localization to plasma membrane; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of angiotensin-activated signaling pathway; regulation of cell junction assembly; regulation of cellular response to hypoxia; regulation of circadian rhythm; regulation of establishment of endothelial barrier; regulation of keratinocyte differentiation; regulation of nervous system process; regulation of protein metabolic process; regulation of synapse maturation; response to angiotensin; response to ischemia; response to transforming growth factor beta; Rho protein signal transduction; rhythmic process; signal transduction; smooth muscle contraction
Reference #:  P70336 (UniProtKB)
Alt. Names/Synonyms: B230113H15Rik; mKIAA0619; p164 ROCK-2; Rho-; Rho-associated coiled-coil containing protein kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; Rho-kinase; Roc; Rock; Rock-II; Rock2; Rock2m; ROKalpha
Gene Symbols: Rock2
Molecular weight: 160,586 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Apoptosis Regulation  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ROCK2

Protein Structure Not Found.


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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene