Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Homodimer. Interacts with IRS1, RHOB and RHOC. Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1. Activated by RHOA binding. Inhibited by Y-27632. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 126.96.36.199; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); ROCK subfamily
Chromosomal Location of Human Ortholog: 12|12 A1.1
Molecular Function: ATP binding; GTP-Rho binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; Rho GTPase binding; Rho-dependent protein serine/threonine kinase activity; transferase activity
Biological Process: actin cytoskeleton organization; actomyosin structure organization; cellular response to acetylcholine; cellular response to testosterone stimulus; centrosome duplication; cortical actin cytoskeleton organization; dendrite morphogenesis; embryonic morphogenesis; extrinsic apoptotic signaling pathway via death domain receptors; I-kappaB kinase/NF-kappaB signaling; intracellular signal transduction; mitotic cytokinesis; mRNA destabilization; negative regulation of angiogenesis; negative regulation of bicellular tight junction assembly; negative regulation of gene expression; negative regulation of myosin-light-chain-phosphatase activity; negative regulation of nitric oxide biosynthetic process; negative regulation of protein localization to lysosome; neural tube closure; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of amyloid precursor protein catabolic process; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cardiac muscle hypertrophy; positive regulation of cell migration; positive regulation of centrosome duplication; positive regulation of connective tissue growth factor production; positive regulation of connective tissue replacement; positive regulation of endothelial cell migration; positive regulation of fibroblast growth factor production; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein localization to early endosome; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; postsynaptic actin cytoskeleton organization; protein localization to plasma membrane; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of angiotensin-activated signaling pathway; regulation of blood vessel diameter; regulation of cell junction assembly; regulation of cellular response to hypoxia; regulation of circadian rhythm; regulation of establishment of endothelial barrier; regulation of keratinocyte differentiation; regulation of neurological system process; regulation of protein metabolic process; response to angiotensin; response to ischemia; response to transforming growth factor beta; Rho protein signal transduction; rhythmic process; smooth muscle contraction; viral RNA genome replication