MRCKA Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; GEK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 13q26
Cellular Component:  actomyosin; cell leading edge; cell-cell junction; cytoplasm; cytoskeleton; lamellipodium
Molecular Function:  ATP binding; identical protein binding; magnesium ion binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  actin cytoskeleton organization; actin cytoskeleton reorganization; actomyosin structure organization; cell migration; cytoskeleton organization; intracellular signal transduction; microtubule cytoskeleton organization; nuclear migration; peptidyl-threonine phosphorylation; protein phosphorylation; regulation of small GTPase mediated signal transduction
Reference #:  O54874 (UniProtKB)
Alt. Names/Synonyms: CDC42 binding protein kinase alpha; CDC42-binding protein kinase alpha; Cdc42bpa; Mrck; MRCK alpha; MRCKA; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; Myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; Pk428; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK alpha
Gene Symbols: Cdc42bpa
Molecular weight: 197,064 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
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MRCKA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene