MRCKA Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; GEK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 1|1 H4
Cellular Component:  actomyosin; cell leading edge; cell projection; cell-cell junction; cytoplasm; cytoskeleton; lamellipodium
Molecular Function:  ATP binding; identical protein binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton organization; actin cytoskeleton reorganization; actomyosin structure organization; cell migration; cytoskeleton organization; intracellular signal transduction; microtubule cytoskeleton organization; nuclear migration; peptidyl-threonine phosphorylation; phosphorylation; protein phosphorylation; regulation of small GTPase mediated signal transduction
Reference #:  Q3UU96 (UniProtKB)
Alt. Names/Synonyms: A930014J19Rik; CDC42 binding protein kinase alpha; CDC42-binding protein kinase alpha; Cdc42bpa; DMPK-l; DMPK-like; Kiaa0451; MGC189823; MRCKA; myotonic dystrophy kinase-related CDC-42-binding kinase-alpha; OTTMUSP00000024352; OTTMUSP00000024384; OTTMUSP00000024385; Serine/threonine-protein kinase MRCK alpha
Gene Symbols: Cdc42bpa
Molecular weight: 195,536 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MRCKA

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene