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MRCKA
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; DMPK family; EC 2.7.11.1; GEK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 1q42.13 |
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Cellular Component:
actomyosin; cell leading edge; cell-cell junction; cytoplasm; cytoskeleton; cytosol; lamellipodium
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Molecular Function:
ATP binding; identical protein binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
actin cytoskeleton organization; actomyosin structure organization; cell migration; peptidyl-threonine phosphorylation; protein phosphorylation
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Reference #:
Q5VT25
(UniProtKB)
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Alt. Names/Synonyms: CDC42 binding protein kinase alpha; CDC42 binding protein kinase alpha (DMPK-like); CDC42 binding protein kinase beta; CDC42 binidng protein kinase beta; CDC42-binding protein kinase alpha; CDC42-binding protein kinase alpha (DMPK-like); CDC42BPA; DKFZp686L1738; DKFZp686P1738; DMPK-like alpha; FLJ23347; KIAA0451; MRCK; MRCK alpha; MRCKA; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; Myotonic dystrophy protein kinase-like alpha; PK428; ser-thr protein kinase PK428; ser-thr protein kinase related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK alpha
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Gene Symbols: CDC42BPA
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Molecular weight:
197,307 Da
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Basal Isoelectric point:
6.16
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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