DMPK2 May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Expressed in heart and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC; GEK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cell leading edge; centriolar satellite; cytoplasm; cytoskeleton; cytosol
Molecular Function:  ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  actin cytoskeleton reorganization; actomyosin structure organization; peptidyl-threonine phosphorylation; protein phosphorylation
Reference #:  Q6DT37 (UniProtKB)
Alt. Names/Synonyms: CDC42 binding protein kinase gamma; CDC42 binding protein kinase gamma (DMPK-like); CDC42-binding protein kinase gamma; CDC42BPG; DMPK-like gamma; DMPK2; HSMDPKIN; KAPPA-200; MRCK gamma; MRCKG; MRCKgamma; Myotonic dystrophy kinase-related CDC42-binding kinase gamma; myotonic dystrophy protein kinase like protein; Myotonic dystrophy protein kinase-like alpha; Myotonic dystrophy protein kinase-like gamma; Serine/threonine-protein kinase MRCK gamma
Gene Symbols: CDC42BPG
Molecular weight: 172,459 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein