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DMPK2
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Expressed in heart and skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; DMPK family; EC 2.7.11.1; GEK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 11q13.1 |
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Cellular Component:
cell leading edge; centriolar satellite; cytoplasm; cytoskeleton; cytosol
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Molecular Function:
ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
actin cytoskeleton organization; actomyosin structure organization; peptidyl-threonine phosphorylation; protein phosphorylation
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Reference #:
Q6DT37
(UniProtKB)
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Alt. Names/Synonyms: CDC42 binding protein kinase gamma; CDC42 binding protein kinase gamma (DMPK-like); CDC42-binding protein kinase gamma; CDC42BPG; DMPK-like gamma; DMPK2; HSMDPKIN; KAPPA-200; MRCK gamma; MRCKG; MRCKgamma; Myotonic dystrophy kinase-related CDC42-binding kinase gamma; myotonic dystrophy protein kinase like protein; Myotonic dystrophy protein kinase-like alpha; Myotonic dystrophy protein kinase-like gamma; Serine/threonine-protein kinase MRCK gamma
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Gene Symbols: CDC42BPG
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Molecular weight:
172,459 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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