DMPK1 Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; GEK subfamily; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 7 A3|7 9.46 cM
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; integral component of mitochondrial outer membrane; membrane; mitochondrial outer membrane; mitochondrion; nuclear membrane; nucleus; plasma membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane
Molecular Function:  ATP binding; kinase activity; metal ion binding; myosin phosphatase regulator activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular calcium ion homeostasis; intracellular signal transduction; muscle cell apoptotic process; nuclear envelope organization; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction; regulation of heart contraction; regulation of myotube differentiation; regulation of skeletal muscle contraction by calcium ion signaling; regulation of sodium ion transport; regulation of synapse structural plasticity
Reference #:  P54265 (UniProtKB)
Alt. Names/Synonyms: DM; DM-kinase; Dm15; DMK; DMPK; DMPK1; dystrophia myotonica kinase, B15; dystrophia myotonica-protein kinase; MDPK; MT-PK; Myotonic dystrophy protein kinase; Myotonin-protein kinase; OTTMUSP00000029595
Gene Symbols: Dmpk
Molecular weight: 69,602 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Select Structure to View Below

DMPK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene