RSK4 Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSKp90 subfamily
Chromosomal Location of human Ortholog: Xq21.1
Cellular Component:  cytoplasm; cytosol; fibrillar center; mitochondrion; nucleolus; nucleoplasm
Molecular Function:  ATP binding; magnesium ion binding; protein binding; protein kinase activity; protein serine kinase activity; ribosomal protein S6 kinase activity
Biological Process:  central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of embryonic development; negative regulation of ERK1 and ERK2 cascade; negative regulation of mesoderm development; peptidyl-serine phosphorylation; signal transduction
Reference #:  Q9UK32 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 6; KS6A6; p90-RSK 6; p90RSK6; pp90RSK4; ribosomal protein S6 kinase A6; Ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase, 90kDa, polypeptide 6; Ribosomal S6 kinase 4; RPS6KA6; RSK-4; RSK4; S6K-alpha 6; S6K-alpha-6
Gene Symbols: RPS6KA6
Molecular weight: 83,872 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Translation: eIF4E and p70S6K
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein