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RSK4
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSK subfamily |
| Chromosomal Location of human Ortholog: Xq21.1 |
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Cellular Component:
cytosol; fibrillar center; mitochondrion; nucleolus; nucleus
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Molecular Function:
ATP binding; magnesium ion binding; protein kinase activity
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Biological Process:
central nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of embryonic development; negative regulation of ERK1 and ERK2 cascade; negative regulation of mesoderm development; protein phosphorylation; signal transduction
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Reference #:
Q9UK32
(UniProtKB)
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Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 6; KS6A6; p90-RSK 6; p90RSK6; pp90RSK4; ribosomal protein S6 kinase A6; Ribosomal protein S6 kinase alpha-6; ribosomal protein S6 kinase, 90kDa, polypeptide 6; Ribosomal S6 kinase 4; RPS6KA6; RSK-4; RSK4; S6K-alpha 6; S6K-alpha-6
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Gene Symbols: RPS6KA6
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Molecular weight:
83,872 Da
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Basal Isoelectric point:
5.92
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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Translation: eIF4E and p70S6K
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