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RNF185
Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of Human Ortholog: 14q21 |
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Cellular Component:
endoplasmic reticulum; integral component of membrane; mitochondrial outer membrane
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Molecular Function:
metal ion binding
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Biological Process:
autophagy; ER-associated protein catabolic process; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Reference #:
Q568Y3
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF185; MGC109455; RING finger protein 185; RN185; Rnf185
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Gene Symbols: Rnf185
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Molecular weight:
20,493 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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