RNF185 Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 14q21
Cellular Component:  endoplasmic reticulum; integral component of membrane; mitochondrial outer membrane
Molecular Function:  metal ion binding
Biological Process:  autophagy; ER-associated protein catabolic process; protein autoubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Reference #:  Q568Y3 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF185; MGC109455; RING finger protein 185; RN185; Rnf185
Gene Symbols: Rnf185
Molecular weight: 20,493 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene