RNF185
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase |
Chromosomal Location of mouse Ortholog: 11|11 A1 |
Cellular Component:
endoplasmic reticulum; membrane; mitochondrial outer membrane; mitochondrion
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Molecular Function:
metal ion binding; protein-containing complex binding; transferase activity; ubiquitin binding; ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding
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Biological Process:
autophagy; defense response to virus; ER-associated misfolded protein catabolic process; ERAD pathway; immune system process; innate immune response; positive regulation of ERAD pathway; positive regulation of innate immune response; positive regulation of type I interferon-mediated signaling pathway; protein autoubiquitination; protein K27-linked ubiquitination; ubiquitin-dependent ERAD pathway; ubiquitin-dependent protein catabolic process
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Reference #:
Q91YT2
(UniProtKB)
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Alt. Names/Synonyms: 1700022N24Rik; AL033296; E3 ubiquitin-protein ligase RNF185; MGC19394; OTTMUSP00000005218; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185; RN185; Rnf185
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Gene Symbols: Rnf185
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Molecular weight:
20,520 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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