PPP1CA Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy. (Microbial infection) Necessary for alphaviruses replication. Belongs to the PPP phosphatase family. PP-1 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  cell-cell adherens junction; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; glycogen granule; neuron projection; neuronal cell body; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; perikaryon; plasma membrane; postsynapse; presynapse; protein phosphatase type 1 complex; PTW/PP1 phosphatase complex
Molecular Function:  cadherin binding involved in cell-cell adhesion; metal ion binding; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein phosphatase 1 binding; protein serine/threonine phosphatase activity; protein-containing complex binding; ribonucleoprotein complex binding
Biological Process:  branching morphogenesis of an epithelial tube; cell division; cell-cell adhesion; circadian regulation of gene expression; dephosphorylation; entrainment of circadian clock by photoperiod; glycogen metabolic process; lung development; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein dephosphorylation; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process; response to lead ion
Reference #:  P62138 (UniProtKB)
Alt. Names/Synonyms: PP-1A; PP1A; Ppp1a; Ppp1ca; protein phosphatase 1, catalytic subunit, alpha isoform; Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1d; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Gene Symbols: Ppp1ca
Molecular weight: 37,512 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  Parkinson's Disease  |  Translation: eIF2
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene