GAMT Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. Expressed in liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Contractile; EC; Methyltransferase
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  cytosol
Molecular Function:  guanidinoacetate N-methyltransferase activity; methyltransferase activity
Biological Process:  animal organ morphogenesis; creatine biosynthetic process; creatine metabolic process; methylation; muscle contraction; regulation of multicellular organism growth; spermatogenesis
Disease: Cerebral Creatine Deficiency Syndrome 2
Reference #:  Q14353 (UniProtKB)
Alt. Names/Synonyms: CCDS2; epididymis secretory protein Li 20; GAMT; Guanidinoacetate N-methyltransferase; HEL-S-20; PIG2; TP53I2
Gene Symbols: GAMT
Molecular weight: 26,318 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein