H3 iso3 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q32.1
Cellular Component:  Barr body; nuclear chromosome; nuclear chromosome, telomeric region; nuclear nucleosome; nucleosome; nucleus; protein-containing complex
Molecular Function:  nucleosomal DNA binding; protein heterodimerization activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding
Biological Process:  brain development; cell proliferation; DNA replication-independent nucleosome assembly; embryo implantation; male gonad development; multicellular organism growth; muscle cell differentiation; negative regulation of chromosome condensation; nucleosome assembly; nucleus organization; oogenesis; osteoblast differentiation; pericentric heterochromatin assembly; positive regulation of cell growth; regulation of centromere complex assembly; response to hormone; single fertilization; spermatid development; spermatogenesis; telomeric heterochromatin assembly
Reference #:  P84245 (UniProtKB)
Alt. Names/Synonyms: H3 histone, family 3B; H3.3b; H3f3b; Histone H3.3; MGC105794
Gene Symbols: H3f3b
Molecular weight: 15,197 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Histone Methylation  |  NF-kB Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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H3 iso3

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  RCSB PDB  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene