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H3 iso3
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of mouse Ortholog: 11|11 E2 |
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Cellular Component:
chromosome, telomeric region; nucleosome; nucleus; protein-containing complex
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Molecular Function:
nucleosomal DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; structural constituent of chromatin
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Biological Process:
cell population proliferation; embryo implantation; male gonad development; multicellular organism growth; muscle cell differentiation; negative regulation of chromosome condensation; nucleus organization; oogenesis; osteoblast differentiation; pericentric heterochromatin formation; regulation of centromere complex assembly; single fertilization; spermatid development; spermatogenesis; subtelomeric heterochromatin formation
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Reference #:
P84244
(UniProtKB)
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Alt. Names/Synonyms: 9430068D06Rik; H3 histone, family 3B; H3 iso3; H3-3a; H3-3b; H3.3 histone B; H3.3a; H3.3b; H33; H3f3a; H3f3b; H3L-like histone; Histone H3.3; OTTMUSP00000003888
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Gene Symbols: H3f3b
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Molecular weight:
15,197 Da
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Basal Isoelectric point:
11.27
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Histone Methylation
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NF-kB Signaling
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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