H3 iso3 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 11|11 E2
Cellular Component:  chromosome, telomeric region; nucleosome; nucleus; protein-containing complex
Molecular Function:  nucleosomal DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; structural constituent of chromatin
Biological Process:  cell population proliferation; embryo implantation; male gonad development; multicellular organism growth; muscle cell differentiation; negative regulation of chromosome condensation; nucleus organization; oogenesis; osteoblast differentiation; pericentric heterochromatin formation; regulation of centromere complex assembly; single fertilization; spermatid development; spermatogenesis; subtelomeric heterochromatin formation
Reference #:  P84244 (UniProtKB)
Alt. Names/Synonyms: 9430068D06Rik; H3 histone, family 3B; H3 iso3; H3-3a; H3-3b; H3.3 histone B; H3.3a; H3.3b; H33; H3f3a; H3f3b; H3L-like histone; Histone H3.3; OTTMUSP00000003888
Gene Symbols: H3f3b
Molecular weight: 15,197 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Histone Methylation  |  NF-kB Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

H3 iso3

Protein Structure Not Found.