CARM1 Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 9|9 A3
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex; RNA polymerase II transcription factor complex
Molecular Function:  histone methyltransferase activity; histone methyltransferase activity (H3-R17 specific); histone-arginine N-methyltransferase activity; lysine-acetylated histone binding; methyltransferase activity; nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; transcription coactivator activity; transcription regulatory region DNA binding; transferase activity
Biological Process:  chromatin organization; endochondral bone morphogenesis; histone arginine methylation; histone H3-R17 methylation; histone H3-R2 methylation; histone methylation; intracellular estrogen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; methylation; negative regulation of dendrite development; negative regulation of protein binding; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein localization to chromatin; protein methylation; regulation of growth plate cartilage chondrocyte proliferation; regulation of intracellular estrogen receptor signaling pathway; regulation of mRNA binding; regulation of transcription, DNA-templated; response to cAMP
Reference #:  Q9WVG6 (UniProtKB)
Alt. Names/Synonyms: Carm1; Coactivator-associated arginine methyltransferase 1; Histone-arginine methyltransferase CARM1; MGC46828; OTTMUSP00000022539; Prm; Prmt4; protein arginine methyltransferase; Protein arginine N-methyltransferase 4
Gene Symbols: Carm1
Molecular weight: 65,854 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA