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GABRB1
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
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Cellular Component:
chloride channel complex; GABA-A receptor complex; GABA-ergic synapse; plasma membrane; postsynaptic membrane; Schaffer collateral - CA1 synapse
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Molecular Function:
G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential; GABA-A receptor activity; GABA-gated chloride ion channel activity; ligand-gated monoatomic ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
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Biological Process:
cellular response to histamine; gamma-aminobutyric acid signaling pathway; monoatomic ion transport; regulation of presynaptic membrane potential
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Reference #:
P08220
(UniProtKB)
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Alt. Names/Synonyms: GABA(A) receptor subunit beta-1; GABRB1; Gamma-aminobutyric acid receptor subunit beta-1; Gamma-aminobutyric-acid receptor subunit beta-1 precursor; GBRB1
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Gene Symbols: GABRB1
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Molecular weight:
54,130 Da
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Basal Isoelectric point:
8.88
Predict pI for various phosphorylation states
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