PKCZ an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Iota subfamily; Kinase, protein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 4 E2|4 86.17 cM
Cellular Component:  apical cortex; apical plasma membrane; axon hillock; bicellular tight junction; cell cortex; cell junction; cell leading edge; cell-cell junction; cytoplasm; cytosol; endosome; glutamatergic synapse; intracellular membrane-bounded organelle; membrane; membrane raft; microtubule organizing center; myelin sheath abaxonal region; nuclear envelope; nuclear matrix; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; Schaffer collateral - CA1 synapse; stress fiber; vesicle
Molecular Function:  14-3-3 protein binding; ATP binding; kinase activity; metal ion binding; nucleotide binding; phospholipase binding; potassium channel regulator activity; protein binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of phospholipase D activity; activation of protein kinase B activity; cell migration; cell surface receptor signaling pathway; cellular protein localization; cellular response to insulin stimulus; establishment of cell polarity; inflammatory response; intracellular signal transduction; long-term memory; long-term synaptic potentiation; membrane depolarization; membrane hyperpolarization; microtubule cytoskeleton organization; negative regulation of apoptotic process; negative regulation of hydrolase activity; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein complex assembly; neuron projection extension; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of ERK1 and ERK2 cascade; positive regulation of excitatory postsynaptic potential; positive regulation of insulin receptor signaling pathway; positive regulation of interleukin-10 secretion; positive regulation of interleukin-13 secretion; positive regulation of interleukin-4 production; positive regulation of interleukin-5 secretion; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein transport; positive regulation of synaptic transmission; positive regulation of T-helper 2 cell cytokine production; positive regulation of T-helper 2 cell differentiation; protein heterooligomerization; protein kinase C signaling; protein localization to plasma membrane; protein phosphorylation; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; signal transduction; vesicle transport along microtubule
Reference #:  Q02956 (UniProtKB)
Alt. Names/Synonyms: AI098070; aPKCzeta; C80388; KPCZ; nPKC-zeta; OTTMUSP00000011359; OTTMUSP00000011362; Pkcz; Prkcz; protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, zeta; R74924; zetaPKC
Gene Symbols: Prkcz
Molecular weight: 67,682 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene