PGAM2 Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC (synthase), but with a reduced activity. Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. Expressed in the heart and muscle. Not found in the liver and brain. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; EC; EC; Isomerase; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 14q21
Cellular Component:  cytosol; nucleus
Molecular Function:  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; cofactor binding; hydrolase activity; phosphoglycerate mutase activity
Biological Process:  gluconeogenesis; glycolytic process; Notch signaling pathway; response to inorganic substance; response to mercury ion; spermatogenesis; striated muscle contraction
Reference #:  P16290 (UniProtKB)
Alt. Names/Synonyms: BPG-dependent PGAM 2; D14Mgh1; Muscle-specific phosphoglycerate mutase; PGAM-M; Pgam2; Pgmut; Phosphoglycerate mutase 2; phosphoglycerate mutase 2 (muscle); Phosphoglycerate mutase isozyme M
Gene Symbols: Pgam2
Molecular weight: 28,755 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene