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PAK2
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of mouse Ortholog: 16 B2|16 22.4 cM |
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Cellular Component:
cell-cell junction; cytoplasm; cytosol; glutamatergic synapse; membrane; nucleus; postsynaptic density; secretory granule
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Molecular Function:
ATP binding; catalytic activity; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; small GTPase binding; transferase activity
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Biological Process:
adherens junction assembly; apoptotic process; bicellular tight junction assembly; cellular response to organic cyclic compound; dendritic spine development; intracellular signal transduction; localization; metabolic process; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; negative regulation of stress fiber assembly; peptidyl-serine phosphorylation; phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein autophosphorylation; protein localization to cell-cell junction; protein phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization; regulation of MAPK cascade
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Reference #:
Q8CIN4
(UniProtKB)
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Alt. Names/Synonyms: 5330420P17Rik; A130002K10Rik; AI836325; D16Ertd269; D16Ertd269e; Gamma-PAK; KIAA4182; mKIAA4182; OTTMUSP00000028355; p21 (RAC1) activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK; PAK-2; PAK-2p27; PAK-2p34; Pak2; Serine/threonine-protein kinase PAK 2
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Gene Symbols: Pak2
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Molecular weight:
57,930 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Microtubule Dynamics
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TGF-ß Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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