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NFM
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Belongs to the intermediate filament family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 14|14 D1 |
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Cellular Component:
axon; cell projection; cytoplasm; cytoskeleton; intermediate filament; intermediate filament cytoskeleton; neurofibrillary tangle; neurofilament; neuromuscular junction; neuron projection; perikaryon; postsynaptic density; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton
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Molecular Function:
protein-containing complex binding; signaling receptor binding; structural constituent of cytoskeleton; structural molecule activity; toxic substance binding
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Biological Process:
axo-dendritic transport; intermediate filament bundle assembly; intermediate filament cytoskeleton organization; intermediate filament polymerization or depolymerization; microtubule cytoskeleton organization; neurofilament bundle assembly; neurofilament cytoskeleton organization; regulation of axon diameter
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Reference #:
P08553
(UniProtKB)
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Alt. Names/Synonyms: 160 kDa neurofilament protein; Nef; Nef3; Nefm; Neurofilament 3; neurofilament 3, medium; Neurofilament medium polypeptide; neurofilament protein M; Neurofilament triplet M protein; neurofilament, medium polypeptide; neurofilament-M; NF-; NF-M; NF16; NF160; NF165; Nfm; OTTMUSP00000017611
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Gene Symbols: Nefm
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Molecular weight:
95,916 Da
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Basal Isoelectric point:
4.76
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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