GLDN Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component:  axon; cell surface; collagen trimer; extracellular space; integral component of membrane; plasma membrane
Molecular Function:  protein binding involved in heterotypic cell-cell adhesion
Biological Process:  clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; microvillus organization
Disease: Lethal Congenital Contracture Syndrome 11
Reference #:  Q6ZMI3 (UniProtKB)
Alt. Names/Synonyms: CLOM; collomin; COLM; colmedin; CRG-L2; CRGL2; FLJ23917; GLDN; Gliomedin; UNC-112
Gene Symbols: GLDN
Molecular weight: 58,957 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB