MRLC2V Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly. Note: This description may include information from UniProtKB.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cardiac myofibril; contractile fiber; cytoplasm; cytoskeleton; myofibril; myosin complex
Molecular Function:  actin monomer binding; calcium ion binding; metal ion binding
Biological Process:  cardiac muscle contraction; cardiac myofibril assembly; heart contraction; heart development; heart morphogenesis; muscle cell fate specification; muscle fiber development; negative regulation of cell growth; positive regulation of the force of heart contraction; post-embryonic development; regulation of the force of heart contraction; ventricular cardiac muscle tissue morphogenesis
Reference #:  P51667 (UniProtKB)
Alt. Names/Synonyms: Gm32672; Mlc; MLC-; MLC-2; MLC-2s/v; MLC-2v; Mlc2v; MLRV; MRLC2V; Myl; Myl2; Mylpc; Myosin light chain 2, slow skeletal/ventricular muscle isoform; myosin light chain 2v; myosin light chain, phosphorylatable, cardiac ventricles; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light polypeptide 2, regulatory, cardiac, slow; OTTMUSP00000029571; OTTMUSP00000029619; ventricular myosin regulatory light chain
Gene Symbols: Myl2
Molecular weight: 18,864 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MRLC2V

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene