MRLC2V myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. Note: This description may include information from UniProtKB.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cardiac myofibril; contractile fiber; cytoplasm; cytoskeleton; myofibril; myosin complex
Molecular Function:  actin monomer binding; calcium ion binding; metal ion binding
Biological Process:  cardiac muscle contraction; cardiac myofibril assembly; heart contraction; heart development; heart morphogenesis; muscle cell fate specification; muscle fiber development; negative regulation of cell growth; positive regulation of the force of heart contraction; post-embryonic development; regulation of the force of heart contraction; ventricular cardiac muscle tissue morphogenesis
Reference #:  P51667 (UniProtKB)
Alt. Names/Synonyms: MLC-2; MLC-2v; Mlc2v; MLRV; Myl2; Mylpc; myosin light chain 2v; myosin light chain, phosphorylatable, cardiac ventricles; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light polypeptide 2, regulatory, cardiac, slow; OTTMUSP00000029571; OTTMUSP00000029619; ventricular myosin regulatory light chain
Gene Symbols: Myl2
Molecular weight: 18,864 Da
Basal Isoelectric point: 4.86  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene