CAMK4 Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK1 family; EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 18 B1|18 18.15 cM
Cellular Component:  cytoplasm; fibrillar center; GABA-ergic synapse; glutamatergic synapse; nucleoplasm; nucleus; postsynapse
Molecular Function:  ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  adaptive immune response; immune system process; inflammatory response; intracellular signal transduction; long-term memory; myeloid dendritic cell differentiation; neuron-neuron synaptic transmission; nucleocytoplasmic transport; peptidyl-serine phosphorylation; phosphorylation; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-templated; postsynapse to nucleus signaling pathway; protein autophosphorylation; protein phosphorylation; signal transduction
Reference #:  P08414 (UniProtKB)
Alt. Names/Synonyms: A430110E23Rik; AI666733; Ca2+/calmodulin-dependent protein kinase type IV/Gr; calcium/calmodulin-dependent protein kinase IV; Calcium/calmodulin-dependent protein kinase type IV; CaM kinase-GR; CaMK IV; Camk4; CaMKIV; CaMKIV/Gr; D18Bwg0362e; KCC4
Gene Symbols: Camk4
Molecular weight: 52,628 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CAMK4

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene