KIF2A Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 13|13 D2.1
Cellular Component:  centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytoskeleton; kinesin complex; lysosome; microtubule; nuclear body; nucleolus; nucleus; sperm principal piece
Molecular Function:  ATP binding; ATPase activity; microtubule binding; microtubule motor activity; nucleotide binding; protein kinase binding
Biological Process:  cell cycle; cell differentiation; cell division; microtubule cytoskeleton organization; microtubule-based movement; mitotic spindle assembly; mitotic spindle organization; multicellular organism development; nervous system development; regulation of cell migration
Reference #:  P28740 (UniProtKB)
Alt. Names/Synonyms: Kif2; KIF2A; Kinesin-2; Kinesin-like protein KIF2A; Kns2
Gene Symbols: Kif2a
Molecular weight: 79,756 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein