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KIF2A
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of mouse Ortholog: 13|13 D2.1 |
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Cellular Component:
centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytoskeleton; kinesin complex; lysosome; microtubule; nuclear body; nucleolus; nucleoplasm; sperm principal piece; spindle; spindle microtubule; spindle pole
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Molecular Function:
ATP binding; ATP hydrolysis activity; microtubule binding; microtubule motor activity; nucleotide binding; protein kinase binding
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Biological Process:
cell cycle; cell differentiation; cell division; microtubule cytoskeleton organization; microtubule-based movement; mitotic spindle assembly; mitotic spindle organization; multicellular organism development; nervous system development; regulation of cell migration
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Reference #:
P28740
(UniProtKB)
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Alt. Names/Synonyms: C530030B14Rik; Kif; Kif2; KIF2A; kinesin family member 2A; kinesin heavy chain member 2; Kinesin-2; Kinesin-like protein KIF2A; Kns2; M-ki; M-kinesin
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Gene Symbols: Kif2a
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Molecular weight:
79,756 Da
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Basal Isoelectric point:
6.31
Predict pI for various phosphorylation states
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