CRMP-2 Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14 D1|14 34.6 cM
Cellular Component:  axon; cytoplasm; cytoskeleton; cytosol; dendrite; growth cone; myelin sheath; neuron projection; neuronal cell body; plasma membrane; presynapse; protein-containing complex
Molecular Function:  hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; identical protein binding; microtubule binding; protein binding; protein kinase binding
Biological Process:  axon guidance; brain development; cell differentiation; cytoskeleton organization; endocytosis; multicellular organism development; nervous system development; positive regulation of glutamate secretion; regulation of axon extension; regulation of neuron differentiation; regulation of neuron projection development; synaptic vesicle transport
Reference #:  O08553 (UniProtKB)
Alt. Names/Synonyms: AI851130; collapsin response mediator protein 2; Crm; CRMP-2; Crmp2; dihydropyrimidinase-like 2; Dihydropyrimidinase-related protein 2; DPYL2; Dpysl2; DRP-2; DRP2; Musunc33; OTTMUSP00000017622; TOAD-; TOAD-64; ULIP-2; Ulip2; Unc-33-like phosphoprotein 2
Gene Symbols: Dpysl2
Molecular weight: 62,278 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene