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RAD17
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. Belongs to the rad17/RAD24 family. Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 13|13 D1 |
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Cellular Component:
chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; Rad17 RFC-like complex
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Molecular Function:
ATP binding; chromatin binding; DNA clamp loader activity; nucleotide binding
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Biological Process:
cell cycle; cellular response to DNA damage stimulus; DNA damage checkpoint signaling; DNA repair; mitotic DNA replication checkpoint signaling; mitotic intra-S DNA damage checkpoint signaling; multicellular organism development; negative regulation of DNA replication; regulation of phosphorylation
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Reference #:
Q6NXW6
(UniProtKB)
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Alt. Names/Synonyms: 9430035O09Rik; Cell cycle checkpoint protein RAD17; MmRad; MmRad24; Rad17; RAD17 checkpoint clamp loader component; RAD17 homolog; RAD17 homolog (S. pombe)
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Gene Symbols: Rad17
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Molecular weight:
77,391 Da
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Basal Isoelectric point:
5.8
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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