Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Belongs to the p53 family. Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. 12 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor; Tumor suppressor
Molecular Function: DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; MDM2/MDM4 family protein binding; metal ion binding; p53 binding; protein binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process: activation of MAPK activity; apoptotic process; cell cycle; cell cycle arrest; cellular response to DNA damage stimulus; cerebrospinal fluid secretion; digestive tract morphogenesis; forebrain development; hippocampus development; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of cardiac muscle cell proliferation; negative regulation of cell proliferation; negative regulation of JUN kinase activity; negative regulation of neuron apoptotic process; negative regulation of neuron differentiation; neuron development; positive regulation of apoptotic process; positive regulation of apoptotic signaling pathway; positive regulation of cell cycle arrest; positive regulation of cell size; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of oligodendrocyte differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; post-embryonic development; protein tetramerization; regulation of gene expression; regulation of mitotic cell cycle; regulation of neuron apoptotic process; regulation of transcription, DNA-templated; release of cytochrome c from mitochondria