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p70S6K
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Widely expressed. 5 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSKp70 subfamily; Translation |
| Chromosomal Location of mouse Ortholog: 11|11 C |
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Cellular Component:
cell surface; cytoplasm; glutamatergic synapse; membrane; mitochondrial outer membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; synapse
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Molecular Function:
ATP binding; identical protein binding; kinase activity; nucleotide binding; PDZ domain binding; peptide binding; protein binding; protein kinase activity; protein phosphatase 2A binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transferase activity
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Biological Process:
apoptotic process; behavioral fear response; cell cycle; cellular response to dexamethasone stimulus; cellular response to growth factor stimulus; cellular response to insulin stimulus; cellular response to organic cyclic compound; cellular response to type II interferon; G1/S transition of mitotic cell cycle; germ cell development; long-chain fatty acid import into cell; modulation of chemical synaptic transmission; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; phosphorylation; positive regulation of mitotic cell cycle; positive regulation of skeletal muscle tissue growth; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of translational initiation; protein kinase B signaling; protein phosphorylation; regulation of glucose import; regulation of translation; response to insulin; response to nutrient levels; response to tumor necrosis factor; signal transduction; TOR signaling; TORC1 signaling
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Reference #:
Q8BSK8
(UniProtKB)
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Alt. Names/Synonyms: 2610318I15Rik; 4732464A07Rik; 70 kDa ribosomal protein S6 kinase 1; 70kDa; AA959758; AI256796; AI314060; KS6B1; OTTMUSP00000001173; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; p70-S6K 1; p70/85s; p70/85s6k; p70s; p70S6; p70s6k; P70S6K1; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1; Rps6kb1; S6K; S6K-beta-1; S6K1
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Gene Symbols: Rps6kb1
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Molecular weight:
59,146 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Mitochondrial Control of Apoptosis
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mTOR Signaling
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PI3K/Akt Signaling
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Protein Kinase C Signaling
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TGF-ß Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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