CYP2B6 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. Belongs to the cytochrome P450 family. Expressed in liver, lung and heart right ventricle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle
Molecular Function:  anandamide 11,12 epoxidase activity; anandamide 14,15 epoxidase activity; anandamide 8,9 epoxidase activity; arachidonic acid epoxygenase activity; estrogen 2-hydroxylase activity; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; testosterone 16-alpha-hydroxylase activity; testosterone 16-beta-hydroxylase activity
Biological Process:  cellular ketone metabolic process; epoxygenase P450 pathway; organic acid metabolic process; steroid metabolic process; xenobiotic catabolic process; xenobiotic metabolic process
Disease: Efavirenz, Poor Metabolism Of
Reference #:  P20813 (UniProtKB)
Alt. Names/Synonyms: 1,4-cineole 2-exo-monooxygenase; CP2B6; CPB6; CYP2B; CYP2B6; CYP2B7; CYP2B7P; CYPIIB6; Cytochrome P450 2B6; cytochrome P450 family 2 subfamily B member 6; Cytochrome P450 IIB1; cytochrome P450, family 2, subfamily B, polypeptide 6; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; EFVM; IIB1; P450
Gene Symbols: CYP2B6
Molecular weight: 56,278 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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