TSPAN14 Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6. Promotes ADAM10-mediated cleavage of CDH5. Belongs to the tetraspanin (TM4SF) family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14 B|14 22.36 cM
Cellular Component:  cell surface; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; tetraspanin-enriched microdomain
Molecular Function:  enzyme binding
Biological Process:  positive regulation of Notch signaling pathway; protein localization to plasma membrane; protein maturation
Reference #:  Q8QZY6 (UniProtKB)
Alt. Names/Synonyms: AA958793; D14Ertd226e; MGC36554; tetraspanin 14; Tetraspanin-14; Tm4sf14; Transmembrane 4 superfamily member 14; TSN14; Tspan-14; Tspan14
Gene Symbols: Tspan14
Molecular weight: 30,674 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene