|
SEMA3C
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance. Belongs to the semaphorin family. Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 7q21.11 |
|
Cellular Component:
extracellular space
|
|
Molecular Function:
chemorepellent activity; semaphorin receptor binding
|
|
Biological Process:
axon guidance; blood vessel remodeling; cardiac endothelial to mesenchymal transition; cardiac right ventricle morphogenesis; dichotomous subdivision of terminal units involved in salivary gland branching; immune response; limb bud formation; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; neural tube development; outflow tract septum morphogenesis; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; positive regulation of cell migration; post-embryonic development; pulmonary myocardium development; response to xenobiotic stimulus; semaphorin-plexin signaling pathway; somitogenesis
|
|
Reference #:
Q99985
(UniProtKB)
|
|
Alt. Names/Synonyms: SEM3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Sema E; SEMA3C; SEMAE; semaphorin 3C; semaphorin E; Semaphorin-3C; Semaphorin-E; SemE
|
|
Gene Symbols: SEMA3C
|
|
Molecular weight:
85,207 Da
|
|
Basal Isoelectric point:
8.96
Predict pI for various phosphorylation states
|
