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PISD
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.1.1.65; Endoplasmic reticulum; Lipid Metabolism - glycerophospholipid; Lyase |
| Chromosomal Location of human Ortholog: 22q12.2 |
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Cellular Component:
lipid droplet; mitochondrial inner membrane; mitochondrion; nucleus
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Molecular Function:
phosphatidylserine decarboxylase activity
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Biological Process:
lipid droplet formation; mitochondrial protein catabolic process; phosphatidylethanolamine biosynthetic process; protein autoprocessing; regulation of mitochondrion organization
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Disease: Liberfarb Syndrome
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Reference #:
Q9UG56
(UniProtKB)
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Alt. Names/Synonyms: DJ858B16; dJ858B16.2; DKFZp566G2246; LIBF; phosphatidylserine decarboxylase; Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase proenzyme; Phosphatidylserine decarboxylase proenzyme, mitochondrial; PISD; PSD; PSDC; PSSC
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Gene Symbols: PISD
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Molecular weight:
46,672 Da
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Basal Isoelectric point:
9.51
Predict pI for various phosphorylation states
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