NANOG Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation. Interacts with SMAD1 and SALL4. Expressed in testicular carcinoma and derived germ cell tumors. Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. Belongs to the Nanog homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q42
Cellular Component:  nucleolus; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; enhancer sequence-specific DNA binding; identical protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; sequence-specific DNA binding; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  cell dedifferentiation; cell differentiation; cellular response to erythropoietin; cellular response to rapamycin; embryonic pattern specification; endodermal cell fate specification; gonad development; mesodermal cell fate commitment; multidimensional cell growth; negative regulation of BMP signaling pathway; negative regulation of cell differentiation; negative regulation of cell fate commitment; negative regulation of transcription by RNA polymerase II; positive regulation of cell proliferation; positive regulation of mitotic cell cycle; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of cell differentiation; regulation of gene expression; regulation of stem cell division; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to organic cyclic compound; response to organic substance; response to retinoic acid; somatic stem cell population maintenance; stem cell differentiation; stem cell division; stem cell population maintenance; tissue regeneration
Reference #:  D3ZS29 (UniProtKB)
Alt. Names/Synonyms: Nanog; Nanog homeobox
Gene Symbols: Nanog
Molecular weight: 35,163 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein