|
TARM1
May act as receptor. Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface. Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils. Expressed in fetal and adult liver, lung, testis, thymus and spleen. Expressed in blood neutrophils. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 19q13.42 |
|
Cellular Component:
plasma membrane; specific granule membrane; tertiary granule membrane
|
|
Molecular Function:
immunoglobulin receptor binding
|
|
Biological Process:
adaptive immune response; innate immune response; negative regulation of CD4-positive, alpha-beta T cell activation
|
|
Reference #:
B6A8C7
(UniProtKB)
|
|
Alt. Names/Synonyms: OLT-2; OSCAR-like transcript-2; OSCAR-like transcript-2 protein; T cell-interacting, activating receptor on myeloid cells 1; T-cell-interacting, activating receptor on myeloid cells protein 1; TARM1
|
|
Gene Symbols: TARM1
|
|
Molecular weight:
29,455 Da
|
|
Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
|
