LIPT1
Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes. Belongs to the LplA family. Highly expressed in skeletal muscle and heart, moderately in kidney and pancreas, and detected at lower levels in liver, brain, placenta and lung. Note: This description may include information from UniProtKB.
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Protein type: Cofactor and Vitamin Metabolism - lipoic acid; EC 2.3.1.-; Transferase |
Chromosomal Location of human Ortholog: 2q11.2 |
Cellular Component:
cytoplasm; mitochondrial matrix; mitochondrion
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Molecular Function:
acyltransferase activity; lipoyltransferase activity; protein binding
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Biological Process:
carboxylic acid metabolic process; lipid metabolic process; protein lipoylation; protein modification process
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Disease: Lipoyltransferase 1 Deficiency
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Reference #:
Q9Y234
(UniProtKB)
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Alt. Names/Synonyms: Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase; lipoyltransferase 1; Lipoyltransferase 1, mitochondrial; LIPT; LIPT1; LIPT1D; MGC12290; MGC13378
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Gene Symbols: LIPT1
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Molecular weight:
42,479 Da
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Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
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