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KLHL31
Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and heart tissues. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 6p12.1 |
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Cellular Component:
cytoplasm; nucleus
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Biological Process:
negative regulation of JNK cascade; negative regulation of protein phosphorylation
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Reference #:
Q9H511
(UniProtKB)
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Alt. Names/Synonyms: bA345L23.2; BKLHD6; BTB and kelch domain-containing protein 6; KBTBD1; kelch like family member 31; kelch repeat and BTB (POZ) domain containing 1; Kelch repeat and BTB domain-containing protein 1; kelch-like 31 (Drosophila); Kelch-like protein 31; Kelch-like protein KLHL; KLH31; KLHL; KLHL31
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Gene Symbols: KLHL31
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Molecular weight:
70,246 Da
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Basal Isoelectric point:
6.3
Predict pI for various phosphorylation states
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