KERA May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664). Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q21.33
Cellular Component:  extracellular matrix; extracellular region; Golgi lumen; lysosomal lumen
Biological Process:  cornea development in camera-type eye; keratan sulfate biosynthetic process; keratan sulfate catabolic process; response to stimulus; visual perception
Disease: Cornea Plana 2
Reference #:  O60938 (UniProtKB)
Alt. Names/Synonyms: CNA2; cornea plana 2 (autosomal recessive); KERA; Keratan sulfate proteoglycan keratocan; Keratocan; keratocan proteoglycan; KTN; SLRR2B
Gene Symbols: KERA
Molecular weight: 40,509 Da
Basal Isoelectric point: 7.11  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene