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PPM1K
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Belongs to the PP2C family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 4q22.1 |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
metal ion binding; myosin phosphatase activity; protein binding; protein serine/threonine phosphatase activity
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Biological Process:
peptidyl-threonine dephosphorylation
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Disease: Maple Syrup Urine Disease, Mild Variant
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Reference #:
Q8N3J5
(UniProtKB)
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Alt. Names/Synonyms: BDP; branched-chain alpha-ketoacid dehydrogenase phosphatase; branched-chain I+/--ketoacid dehydrogenase phosphatase; DKFZp667B084; DKFZp761G058; hPTMP; MSUDMV; PP2C domain-containing protein phosphatase 1K; PP2C type mitochondrial phosphatase; PP2C-kappa; PP2C-like mitochondrial protein; PP2C-like protein; PP2C-type mitochondrial phosphoprotein phosphatase; PP2Ckappa; PP2CM; PPM1K; protein phosphatase 1K (PP2C domain containing); Protein phosphatase 1K, mitochondrial; Protein phosphatase 2C isoform kappa; protein phosphatase 2C kappa; protein phosphatase, Mg2+/Mn2+ dependent 1K; protein phosphatase, Mg2+/Mn2+ dependent, 1K; PTMP; UG0882E07
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Gene Symbols: PPM1K
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Molecular weight:
40,997 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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