PPM1K Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Belongs to the PP2C family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 4q22.1
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  metal ion binding; myosin phosphatase activity; protein binding; protein serine/threonine phosphatase activity
Biological Process:  peptidyl-threonine dephosphorylation
Disease: Maple Syrup Urine Disease, Mild Variant
Reference #:  Q8N3J5 (UniProtKB)
Alt. Names/Synonyms: BDP; branched-chain alpha-ketoacid dehydrogenase phosphatase; branched-chain I+/--ketoacid dehydrogenase phosphatase; DKFZp667B084; DKFZp761G058; hPTMP; MSUDMV; PP2C domain-containing protein phosphatase 1K; PP2C type mitochondrial phosphatase; PP2C-kappa; PP2C-like mitochondrial protein; PP2C-like protein; PP2C-type mitochondrial phosphoprotein phosphatase; PP2Ckappa; PP2CM; PPM1K; protein phosphatase 1K (PP2C domain containing); Protein phosphatase 1K, mitochondrial; Protein phosphatase 2C isoform kappa; protein phosphatase 2C kappa; protein phosphatase, Mg2+/Mn2+ dependent 1K; protein phosphatase, Mg2+/Mn2+ dependent, 1K; PTMP; UG0882E07
Gene Symbols: PPM1K
Molecular weight: 40,997 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene