GUCY2F Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Note: This description may include information from UniProtKB.
Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.
Chromosomal Location of Human Ortholog: Xq22.3-q23
Cellular Component:  integral component of plasma membrane; nuclear outer membrane; photoreceptor disc membrane
Molecular Function:  ATP binding; GTP binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; signaling receptor activity
Biological Process:  cGMP-mediated signaling; detection of light stimulus involved in visual perception; protein phosphorylation; regulation of rhodopsin mediated signaling pathway; visual perception
Reference #:  P51841 (UniProtKB)
Alt. Names/Synonyms: CYGF; GC-F; guanylate cyclase 2D-like, membrane (retina-specific); guanylate cyclase 2F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; GUC2DL; GUC2F; GUCY2F; RETGC-2; RETGC2; Retinal guanylyl cyclase 2; Rod outer segment membrane guanylate cyclase 2; ROS-GC2
Gene Symbols: GUCY2F
Molecular weight: 124,850 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Select Structure to View Below

GUCY2F

Protein Structure Not Found.

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