GUCY2F a transmembrane guanylyl cyclase enzyme with a tyrosine kinse domain. Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells. The pseudokinase domains of guanylyl cyclases have been reported to allosterically increase the affinity of their catalytic domains for substrate. Note: This description may include information from UniProtKB.
Protein type: EC; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.
Chromosomal Location of Human Ortholog: Xq22.3-q23
Cellular Component:  integral component of plasma membrane; nuclear outer membrane; photoreceptor disc membrane
Molecular Function:  ATP binding; GTP binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; signaling receptor activity
Biological Process:  cGMP-mediated signaling; detection of light stimulus involved in visual perception; protein phosphorylation; regulation of rhodopsin mediated signaling pathway; visual perception
Reference #:  P51841 (UniProtKB)
Alt. Names/Synonyms: CYGF; GC-F; guanylate cyclase 2D-like, membrane (retina-specific); guanylate cyclase 2F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; GUC2DL; GUC2F; GUCY2F; RETGC-2; RETGC2; Retinal guanylyl cyclase 2; Rod outer segment membrane guanylate cyclase 2; ROS-GC2
Gene Symbols: GUCY2F
Molecular weight: 124,850 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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