ELOVL5 Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid. Belongs to the ELO family. ELOVL5 subfamily. Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9|9 E1
Cellular Component:  cell projection; dendritic tree; endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane; neuronal cell body
Molecular Function:  3-oxo-arachidoyl-CoA synthase activity; 3-oxo-cerotoyl-CoA synthase activity; 3-oxo-lignoceronyl-CoA synthase activity; fatty acid elongase activity; transferase activity
Biological Process:  fatty acid biosynthetic process; fatty acid elongation, monounsaturated fatty acid; fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; fatty acid metabolic process; lipid metabolic process; positive regulation of fatty acid biosynthetic process; sphingolipid biosynthetic process; very long-chain fatty acid biosynthetic process
Reference #:  Q8BHI7 (UniProtKB)
Alt. Names/Synonyms: 1110059L23Rik; 3-keto acyl-CoA synthase Elovl5; AI747313; AU043003; Elongation of very long chain fatty acids protein 5; ELOV5; ELOVL FA elongase 5; ELOVL family member 5, elongation of long chain fatty acids (yeast); ELOVL fatty acid elongase 5; Elovl5; fatty acid elongase 1; FEN1/Elo2, SUR4/Elo3-like; HELO1; homolog of yeast long chain polyunsaturated fatty acid elongation enzyme; OTTMUSP00000026486; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5
Gene Symbols: Elovl5
Molecular weight: 35,332 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene