SCAP Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Belongs to the WD repeat SCAP family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi apparatus; Golgi membrane; integral component of membrane; protein-containing complex
Molecular Function:  protein binding; protein-containing complex binding; sterol binding; unfolded protein binding
Biological Process:  aging; cellular lipid metabolic process; cholesterol metabolic process; immune response; negative regulation of cholesterol biosynthetic process; positive regulation of low-density lipoprotein particle receptor biosynthetic process; regulation of fatty acid biosynthetic process; response to hypoxia; response to insulin; SREBP signaling pathway
Reference #:  Q12770 (UniProtKB)
Alt. Names/Synonyms: KIAA0199; SCAP; SREBF chaperone; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein; Sterol regulatory element-binding protein cleavage-activating protein
Gene Symbols: SCAP
Molecular weight: 139,729 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene