TIF1G an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; EC; Kinase, protein; Ligase; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3|3 F2.2
Cellular Component:  nucleus
Molecular Function:  co-SMAD binding; DNA binding; metal ion binding; protein binding; R-SMAD binding; transferase activity; zinc ion binding
Biological Process:  negative regulation of BMP signaling pathway; protein ubiquitination; regulation of transforming growth factor beta receptor signaling pathway
Reference #:  Q99PP7 (UniProtKB)
Alt. Names/Synonyms: 8030451N04Rik; AI413936; DKFZp586K1123; E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; Kiaa1113; mKIAA1113; TIF1-gamma; Tif1g; Transcription intermediary factor 1-gamma; TRI33; Trim33; tripartite motif protein 33; tripartite motif-containing 33; Tripartite motif-containing protein 33
Gene Symbols: Trim33
Molecular weight: 123,843 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene