TIF1G Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). Belongs to the TRIM/RBCC family. Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; EC 6.3.2.-; EC; Kinase, protein; Ligase; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3|3 F2.2
Cellular Component:  nucleus
Molecular Function:  co-SMAD binding; DNA binding; metal ion binding; protein binding; R-SMAD binding; transferase activity; zinc ion binding
Biological Process:  negative regulation of BMP signaling pathway; protein ubiquitination; regulation of transforming growth factor beta receptor signaling pathway
Reference #:  Q99PP7 (UniProtKB)
Alt. Names/Synonyms: 8030451N04Rik; AI413936; DKFZp586K1123; E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; Kiaa1113; mKIAA1113; TIF1-gamma; Tif1g; Transcription intermediary factor 1-gamma; TRI33; Trim33; tripartite motif protein 33; tripartite motif-containing 33; Tripartite motif-containing protein 33
Gene Symbols: Trim33
Molecular weight: 123,843 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene